Scientist I/Scientist II, Chemical Development

CompanyNurix Therapeutics ( is a public biopharmaceutical company developing novel small molecule immune modulators for the treatment of cancer and autoimmune diseases. Based on the successful progress of our R&D platform, including expertise in medicinal chemistry, immune cell biology and in vivo pharmacology, Nurix is advancing multiple programs to the clinical stage. The company's lead drugs are a novel protein degradation agent for blood borne tumors and a mechanistically novel oral, immunomodulatory agent for solid tumors.The candidate will be responsible for chemical development-related activities across the portfolio including process development and manufacture of regulatory starting materials (RSMs) and supporting production of Drug Substance (DS) for clinical trial materials, and establishment of associated control strategy for RSMs and DS to support CMC regulatory documents. The ideal candidate will be a highly motivated chemist with experience and interest in working in a small, entrepreneurial environment with broad responsibilities and opportunities.Principal Duties and ResponsibilitiesDevelopment of robust, scalable, and cost-effective phase-appropriate manufacturing process that meet or exceed quality and regulatory requirementsWork up to 50% of the time in the lab to support process route development and ongoing production campaignsResponsible for supporting RSMs and DS manufacturing related activities, including scale-up of compounds to support internal and external drug developmentAuthor tech transfer documents and work with CROs/CDMOs to effectively and efficiently reproduce chemistry at various sitesSupport phase-appropriate process characterization, identify critical quality attributes, and implement controls, including selection and justification of RSMs to ensure that all CROs and CMOs are using systems and processes in compliance with all relevant regulatory standards and to ensure consistency of DS qualityPrepare, review, or edit technical reports, protocols, cGMP batch records, CMC regulatory submissions and Quality documentsCollaborate with cross-functional teams, including analytical chemistry, formulation, quality and regulatory to support drug development programsTravel up to 25%Skills and BackgroundPhD with 2+ years of experience or MS with 5+ years of experience; advanced degree in Organic Chemistry, Chemical Engineering, Pharmaceutical Chemistry, Pharmaceutics, Pharmaceutical Science, or related scientific discipline1-3 years relevant experience in a pharmaceutical or biotechnology CMC/cGMP environment preferredHands-on experience in multi-steps organic synthesis. Familiarity with common analytical techniques (e.g., HPLC, NMR, mass spectrometry)Strong working knowledge of synthetic organic chemistry and the ability to leverage it toward route development and rapid synthetic triageExperience leveraging US and International CRO/CMOs for the manufacture of RSMs and DS to meet aggressive timelinesExcellent problem-solving skills and the ability to identify, resolve critical issues, and work independentlyExperience implementing technical, strategic, and operational plansExcellent written and verbal communication skills, exceptional interpersonal and management skills to collaborate with and direct the work of others on assigned projects (including both internal teams and external collaborators)Strongly team oriented#J-18808-Ljbffr

Created: 2025-02-26