Principal Scientist, Pharmacokinetics

Job DescriptionBoston Pharmacokinetics, Dynamics, Metabolism and Bioanalytics - R5 Principal ScientistAt our Company, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At our Company's Research Labs- Boston, you'll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.The Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) group is seeking a dynamic, strategic thinking and collaborative Principal Scientist (director-level equivalent) to contribute to our Company's drug discovery and early clinical development efforts. This position will be based at our research labs in Boston, MA. The ideal candidate will lead drug metabolism and pharmacokinetic (DMPK) efforts across multiple modalities (small molecules, peptides, protein therapeutics) as a project-team representative, regularly interacting with multi-disciplinary discovery teams and partners from other functions within our Research & Development Division. Therapeutic area support with focus on our immunology and oncology portfolios, with the potential to contribute to cardiovascular/metabolic, neuroscience and infectious disease efforts as well. The successful candidate will be expected to represent PDMB on cross-functional teams through strategic design of discovery testing funnels, generation and interpretation of PK and PK/PD data sets and through effective communication at both internal meetings and external conferences.In this exciting position, your primary roles will include:Project-team representative and subject matter expert on multiple modality DMPK activities within the oncology and immunology therapeutic areasCharacterization and optimization of the in vitro and in vivo ADME and pharmacokinetic properties of small molecules and peptide therapeuticsDesign, implementation and analysis of in vitro and in vivo studies to understand the impact of drug disposition on disease biology, pharmacological response (PK/PD) and safetyContribute to global DMPK strategy through close collaboration with Discovery and Early Development project teams in Boston (MA), London (UK), South San Francisco (CA) and West Point (PA) focusing on building highly efficient strategies to identify and optimize drug candidatesEducation Minimum RequirementPh.D (with 6+ years relevant experience) or Master's (minimum of 10 years relevant experience) degree in biochemistry, chemistry, pharmacology, pharmaceutical sciences, biomedical engineering or related field; Relevant experience to include a record of increasing responsibility and independence in a similar industrial/academic settingRequired Experience and SkillsDemonstrated experience leading multiple small molecule, peptide and/or protein therapeutic DMPK discovery efforts as an independent project-team representative within a highly collaborative environmentAbility to design, optimize and interpret DMPK-related optimization strategies (discovery testing funnels) as part of a broader research operating planTechnical ability to analyze, interpret and provide context around data describing the ADME, pharmacokinetic and pharmacodynamic properties of small molecules, peptides and/or protein therapeutics, including use of software such as Phoenix WinNonlinExperience contributing to development and execution of translational pharmacokinetic/pharmacodynamic/efficacy relationships and other useful quantitative pharmacology applications in a discovery settingStrong leadership, interpersonal, communication, problem solving and collaborative qualities to deliver high quality results in a fast-paced environmentPreferred Experience and SkillsHands-on experience performing translational pharmacokinetic/pharmacodynamic/efficacy and physiologically-based pharmacokinetic (PBPK) software modeling (e.g., Phoenix WinNonlin, Berkeley Madonna, MATLAB).Proven track record supporting immunology or oncology-based programs with experience spanning from early discovery through IND-enabling effortsFamiliarity with structure-activity relationships aimed at improving pharmacokinetic and pharmacodynamic properties of small molecules or peptidesExperience working within a research-driven pharmaceutical company#J-18808-Ljbffr

Created: 2025-02-22