Associate Director, Clinical Pharmacology South San ...

Associate Director, Clinical PharmacologyThe Position:At Maze Therapeutics, we harness the power of genetics to drive novel target discovery for common diseases, particularly in renal and cardiometabolic indications. If you're passionate about drug development and scientific problem-solving in a collaborative and innovative environment, we invite you to explore this opportunity.As a key clinical pharmacology expert, you will thrive in a fast-paced, cross-functional setting, contributing to the design and execution of clinical pharmacology and proof-of-concept patient trials. You'll also lead hands-on data analysis and help define the Clinical Pharmacology strategy as part of the broader Clinical Development plan. Reporting directly to the Head of Clinical Pharmacology, this role offers high visibility and a significant opportunity to make an impact.The Impact You'll HaveLead Clinical Pharmacology Studies : Design and execute studies supporting the overall Clinical Pharmacology strategy, including FIH, DDI, rBA/BE, ADME, TQT and special population studies.Drive Translational Science : Collaborate with internal teams (e.g. In-vivo/In-vitro Pharmacology, DMPK, and Biology) to develop translational PK/PD models.Analyze & Interpret Data : Conduct pharmacokinetic (PK) and pharmacodynamic (PD) data analyses, including noncompartmental and compartment approaches, data visualization and summary reports.Regulatory Contributions : Co-author and review key regulatory documents (IND/CTAs, clinical protocols, study reports, population PK reports, investigator brochures, and other filings).Stay at the Forefront : Keep up with emerging clinical pharmacology trends, quantitative methods, and regulatory best practices to enhance Maze's development programs.Scientific Communication : Support the preparation of presentations and manuscripts and attend scientific conferences.As an Associate Director, we also expect you to demonstrate the following Leadership Competencies:Communication and InfluenceBuilds communication channels across Maze for sharing informationInfluences Senior Management decisions through persuasive argumentsRespectfully addresses differing opinions leading to support of decisionTeamwork and CollaborationChampions partnerships and connections across MazeProactively addresses issues that could result in breakdown of team relationshipsSpotlights team and individual contributions in public forumsExecution and ResultsAddresses gaps and leverages strengths to get best resultsMaintains a steadying presence and clarifies priorities during changeAnticipates and removes barriers that put functional/corporate goals at riskDevelop Others and SelfRemoves barriers to staff development and empowers them to make their own decisionsStays current on industry trends and keeps direct-reports prepared and responsiveWhat We're Looking ForPhD in Pharmacology and/or PharmD with at least of 3+ years of industry experience in clinical pharmacology or pharmacometrics, preferably with small molecules.Experience in renal disease drug development is a plus.Strong track record in clinical trial design, pharmacology data analysis, and regulatory submissions (INDs, NDAs, MAAs).Hand-on experience in pharmacometrics or Quantitative Pharmacology is a plus.Thorough understanding of global regulatory guidelines related to clinical pharmacology including modeling best practices, drug/food interactions, and pediatric drug development regulations (PREA/BPCA and European Commission guidelines).Proven ability to manage external vendors effectively.Exceptional organizational, analytical, and communication skills, ensuring high-quality, timely data delivery.A curious, adaptable, and collaborative mindset, with the ability to work independently and cross-functionally.Ability to travel as needed for conferences, site visits, and regulatory meetings.About Maze TherapeuticsMaze Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel, small molecule precision medicines for patients living with renal, cardiovascular and related metabolic diseases, including obesity. The company is advancing a pipeline using its Compass platform, which allows it to identify and characterize genetic variants in disease and then link those variants to the biological pathways that drive disease in specific patient groups through a process it refers to as variant functionalization. The company's pipeline is led by two wholly owned lead programs, MZE829 and MZE782, each of which represents a novel precision medicine-based approach for chronic kidney disease. Maze is based in South San Francisco.Our PeopleMaze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.Our Core ValuesFurther Together- Our path is paved with challenges, but with resilience and a team-first mentality, we'll achieve our mission.Impact Obsessed- We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.Stand True- Our integrity is foundational; it guides us no matter the obstacle.The expected annual salary range for employees located in the San Francisco Bay Area is $203,000 to $248,000. Additionally, this position is eligible for an annual performance bonus.Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.Apply for this jobInterested in building your career at Maze Therapeutics? Get future opportunities sent straight to your email.#J-18808-Ljbffr

Created: 2025-02-17