Director Human Performance

Vividion is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome-wide footprinting of drug-protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered "undruggable". Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first in class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein-protein interaction inhibitors, functional activators, degraders etc.) against undruggable targets in the oncology and immunology space.We prize scientific excellence, creativity, team players and we are committed to continued innovation. We have worked hard to create a collaborative and dynamic work culture where your ideas and discoveries are valued and will have an impact. We are growing and there are opportunities for mentorship and career progression.Vividion has been recognized as a Top Workplace by The San Diego Union-Tribune in 2022, 2023, and 2024.Job Summary :We are seeking a Director or Senior Director, CMC Preformulation Sciences to join our growing Chemistry, Manufacturing, and Controls (CMC) team. This leadership role will drive preclinical formulation strategies, ensuring the seamless translation of discovery compounds into clinical candidates. The successful candidate will be responsible for evaluating the pharmaceutical properties of drug candidates, guiding formulation strategies for preclinical and early clinical development, and collaborating closely with cross-functional teams (DMPK, Toxicology, Pharmacology, Medicinal Chemistry) to address challenges related to solubility, stability, bioavailability, and drug delivery.This individual will provide strategic leadership and technical expertise in preclinical formulation development while actively contributing to candidate selection, optimization, and progression. A strong ability to lead teams, influence decision-making, and navigate a fast-paced biotech environment is essential.Essential Duties and Responsibilities :Provide strategic leadership in preclinical formulation development, ensuring robust assessment of drug candidates' physicochemical properties and developability.Lead the design, characterization, and optimization of formulations to support in vivo pharmacology, DMPK, and toxicology studies.Integrate preformulation and biopharmaceutics strategies within CMC emphasizing strategic, staged determination of solid state and preclinical formulations to enable early determination of a qTPP driving candidate selection.Serve as the biopharmaceutics lead within CMC, working closely with discovery, DMPK, pharmacology, toxicology, and product development teams to ensure seamless candidate progression.Manage a laboratory-based team to oversee the selection and characterization of solid-state forms (e.g., polymorph / salt selection), including analytical techniques such as PXRD, DSC, TGA, DVS, microscopy, UPLC / HPLC, dynamic light scattering, particle size analysis, and solubility / stability assessments.Develop and implement formulation strategies for poorly soluble small molecules, leveraging techniques such as particle size reduction, lipid-based formulations, amorphous solid dispersions, and self-emulsifying drug delivery systems.Provide guidance on clinical formulation design, including dose selection, administration routes, and early-phase drug product development.Lead and mentor a team of scientists, fostering technical excellence and career development.Establish and manage relationships with external CROs / CDMOs for preclinical and early-phase formulation development.Stay abreast of emerging trends in formulation sciences, drug delivery technologies, and regulatory expectations.Qualifications and Experience :Ph.D. or advanced degree in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or a related discipline.12+ years of industry experience with demonstrated strategic leadership in preclinical formulation and early drug development.Deep understanding of formulation impacts on ADME, preclinical safety, and drug development.Proven track record of successfully advancing drug candidates through preclinical and early clinical development.Experience leading cross-functional teams and influencing strategic decisions, as well as managing a group of internal laboratory scientists and external partners.Strong background in physicochemical characterization and solid-state properties of drug candidates.Expertise in formulation development strategies for challenging molecules, including solubility and bioavailability enhancement approaches.Strong project management skills, with the ability to drive programs forward in a dynamic environment.Excellent written and verbal communication skills, with the ability to present complex data to diverse audiences.Key Attributes :Strategic thinker with a proactive and solution-oriented mindset.Strong leadership and mentoring abilities.Effective collaborator in cross-functional and multidisciplinary teams.Detail-oriented with a commitment to scientific rigor and excellence.Ability to thrive in an entrepreneurial, fast-paced, and innovative biotech environment.Pay & Benefits :The anticipated base salary for this position ranges from $220,000 to $260,000 depending on relevant skills, competencies, experience, and education. In addition, this position is eligible for target bonus, long-term-incentives, 401k retirement savings plan with company match, and a comprehensive benefits package which includes medical, dental, vision, life, and disability insurance.EEO & Employment Eligibility :Vividion Therapeutics, Inc. is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.#J-18808-Ljbffr

Created: 2025-02-14