Skills Alliance | Senior Scientist, Protein ...

About the Role: As a Protein Biochemistry Senior Scientist, you will advance our genetic medicine technologies, enabling the discovery and development of new therapeutics. Working with a diverse team of cell biologists, protein and RNA engineers, computational scientists, molecular biologists, and translational biologists, you will:• Independently generate, troubleshoot and develop novel protein design strategies• Lead the preparation, characterization and functional testing of engineered proteins and ensure timely delivery of reagents to internal stakeholders and potential collaborators• Contribute to the advancement of our multiplexed measurements technology• Interface with internal therapeutic development efforts to facilitate multiplexed screening projects• Maintain data integrity and effectively communicate findings orally and in writing to a multidisciplinary team• Stay up to speed on cutting edge research and industry standards for protein therapeuticsRequirements: • PhD in Chemistry, Biochemistry, Chemical Biology, Bioengineering or similar• Demonstrated knowledge of various techniques and troubleshooting abilities related to protein engineering, e.g. functional library screening, chimeric protein design and optimization, protein labeling (site-specific, lysine, chemical and enzymatic, etc)• Strong hands-on expertise in molecular cloning, protein production, purification and modification • Expertise with a range of analytical methods in protein biochemistry• Proficient in a range of biophysical characterization methods.• Proven track record of solving difficult scientific problems and a desire to learn and tackle new challenges• Courageous, attention to details and data-driven, with a genuine passion for innovative science and developing medicinesPreferred Qualifications:• Expertise in the overexpression of recombinant proteins from prokaryotic and eukaryotic hosts.• High-level competency in designing and running multi-step chromatographic purification strategies utilizing modern AKTA FPLC systems (e.g. í„KTA Pure)• Experience in the assembly and characterization of multi-subunit nucleoprotein complexes• Skilled in the biochemical and biophysical characterization of protein-DNA and proteinRNA interactions.• Strong hands-on experience of high-throughput functional assay development and deployment• Proficiency in binding affinity characterization methods, e.g. EMSA, ITC, MST, SPR, or BLI.• Experience managing CRO workflows and partnerships• A strong working knowledge of cutting-edge therapeutic in vivo delivery strategies.

Created: 2025-01-09