Associate Director/Director, Biology

Remix launched with a vision to transform patient's lives through modulation of RNA processing. Our breakthrough science provides a path to identify small molecules that impact the expression of disease driving mRNAs and proteins. We take on the challenge of addressing drug targets in diseases of high unmet medical need to bring new therapeutic options to patients. Remix has a commitment to demonstrate the highest levels of scientific integrity with urgency because those patients are counting on us to deliver. With an in-house technology platform built from scratch, we have rapidly generated multiple drug discovery programs that are advancing towards the clinic. Position Summary: We seek a highly motivated biologist to join our team in Watertown, MA. This position will report to the Head of Biology and will be responsible for co-leading a multidisciplinary team tasked with driving a small molecule drug discovery program to the clinic. This program targets an oncogenic pathway that has been implicated in a wide variety of malignancies through a novel RNA processing mechanism. The successful candidate will have a strong background in cancer biology and substantial small molecule drug discovery experience. The role will involve both direct management of junior scientists, as well as management of external (CRO) resources. The individual will be expected to contribute to all stages of drug discovery programs, advancing small molecules from hit identification to development candidate selection, and will be driven to succeed within a hypothesis-driven, team-oriented, and interdisciplinary biotech environment. Principal Duties and Responsibilities: Co-lead interdisciplinary project teams and work with a team of scientists to progress projects from target selection and validation through candidate selection Work with the project team to devise a robust and efficient LO cascade, including relevant cellular and in vivo models, to drive multiparametric lead optimization of small molecule therapeutics Coordinate both internal and external (CRO) activities supporting drug discovery activities Interface with external KOLs for input on disease hypothesis, translational models, clinical and regulatory landscape Collaborate with key stakeholders to devise early clinical development path, including biomarker strategy and opportunities for accelerated approval. Possess a clear and effective communication style Provide mentorship to biology team members including identifying and nurturing areas for development Build and maintain productive relationships with colleagues in chemistry, pharmacology, computational biology, biomolecular sciences, and DMPK Qualifications: PhD in cell biology, molecular biology, genetics or a related field 8+ years of experience in an industry setting Strong technical skills including familiarity with modern functional genomics tools Strong publication record and proven track record of success Previous experience in managing both people and projects Ability to effectively communicate to diverse audiences Keen attention to detail and a strong sense of urgency is required as is the desire and ability to work in a multi-disciplinary and team-focused environment Remix values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation, or any other legally protected status. Remix will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Note to Third Party Staffing Agencies : Please do not forward any agency resumes. Remix Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Created: 2024-11-12