Molecular Biologist

Seeking a Molecular Biologist to join a growing Biotech company in the Spring House, PA area. Key Responsibilities: The primary responsibilities of this position include, but are not limited to: Work independently and as part of an interdisciplinary team to support the development and evaluation of non-viral gene therapies using the company's novel DNA scaffold technology. Molecular characterization of biomolecules including DNA-conjugated modalities including peptides, antibodies, proteins, and small molecules. Test various molecules and modalities for biochemical suitability, potential efficacy and safety using cell-based assays combined with various analytical methods.Develop cell and molecular assays to assess cell fate, potency and durability of the delivery scaffold and genetic payloads. Design and test cell-based protocols for transfer to the Development team. Maintain data acquisition and analysis in electronic laboratory notebook. Basic Qualifications: BS degree in Cell Biology, Molecular Biology, Biochemistry, Pharmaceutical Sciences with 2-5 years or a MS degree with 0-2 years of research and development experience. Experience with mammalian cell culture and knowledge on cell based assays.Detail-oriented with strong organizational and communication skills. Experience with DNA and RNA extraction methods and downstream use. Hands-on experience with standard laboratory equipment and procedures. Able to digest complex articles and reviews and pull relevant information, ideas, and methodologies for experimental use. General understanding of cell-based assays and outcomes. Knowledge of peptide and protein structure and function. Basic analytical characterization methods. Preferred SkillsExperience: Experience with flow cytometry cell-based assays for quantitative assessment of results. Experience with qPCR, ddPCR and other qualitative and quantitative nucleic acid analysis methodologies. Experience in performing plate and bead-based pulldown and analytical assays.Able to troubleshoot experiments and instrument issues. Only local candidates will be considered.

Created: 2024-11-09