Scientist, Antibody Discovery

**MULTIPLE OPENINGS**Scientist - Antibody Discovery100% onsite in South San Francisco, CA6-12mth contract (with long term contracting opportunity potential future conversion)Seeking a ScientistSr with background in molecular biology and protein biochemistry to work closely with members of the Antibody Discovery Team to support Large Molecule therapeutic programs.RESPONSIBILITIESDesign strategies and execute antibody discovery campaigns for therapeutic and reagent antibodies using phage displayGenerate antibody fragment libraries for antibody discovery and engineering, perform HT binding screens (ELISA and multi-plex flow cytometry) and sequence analysis to generate hitsRank-order clones by affinity, in vitro potency, and early developability assessmentExecute sequence optimization of lead antibodies to improve developability and binding affinityDesign and clone constructs for mAbs, bispecific, and multi-specific antibodies for recombinant antibody productionSupport NGS-based antibody discovery workflowPresent data and updates to management and project teamsFollow good documentation practice including maintaining good record keeping in Electronic NotebooksREQUIRED QUALIFICATIONS AND BACKGROUNDPhD in Biochemistry, BiomedicalChemical Engineering, Immunology, or related field with minimum of 2 years of post-graduate experience (preferably in industry), MS with 8+ years of research experience, BS with 10+ years of research experience in antibody or protein engineeringSignificant experience in antibody discovery and protein engineering by using single B cell cloning, hybridoma, or phageyeast display techniquesStrong background in molecular biology, antibody and protein expression, and biophysical characterization of recombinant antibodies and proteinsADDITIONAL PREFERENCESExperience in single domain antibodies, multi-specific antibody engineering, Fc engineering, antibody drug conjugates, naí¯ve phage or yeast display library designExperience in NGS analysis for antibody discovery and engineeringSignificant contributions to successful biologics drug discovery programs in industry

Created: 2024-11-06