Principal Process Engineer
Veranova - devens, MA
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Job Title: Principal Process Engineer City: Devens State : MA JOB DESCRIPTION : Develop and implement advanced models and perform data regression for processes in the synthesis of Active Pharmaceutical Ingredients (APIs) using modelling tools: gPROMS®, gFormulate®, ASPEN®, Dynochem®, COMSOL®, OpenFOAM®, SmartFoam®. Develop AI/ML models leveraging industrial data. Data collection, visualization, and model deployment using Knime, or web-based frameworks including Streamlit or Dash. Define experimental workflows for parameter estimation for Spray Drying, Milling, and heterogeneous reactions using analytical equipment. Develop scale-down experiments to de-risk scale-up. Design, commission, and install pilot scale equipment. Provide and test valid explanations for all results. Build capabilities in and integrate PAT, process. Sound grasps of PAT tools from industrial partners: Mettler Toledo - ReactIR, FBRM), Blaze, etc. Develop CFD for Spray Drying, cyclone, Mixing, and Crystallization. Develop and validate CFD models in OpenFoam® software. Meshing with SnappyHexMesh®. Paraview for visualization of the results. Design, and deploy High-Performance computing (HPC) environments either on-prem or Cloud (AWS, Azure) for mathematical models and ML/AI. Conduct detailed analysis of process data to identify areas of improvement and process optimization. Develop Multivariate statistics, and Model Predictive Control (MPC) models to control, predict, and optimize operating conditions using R/MATLAB/Python. Drive innovation, identify, and evaluate new technology opportunities. Identify strategic models from academia/open source, software vendors, and Pharma Consortium to support strategic projects for the business. Present the case study and workflows at external international conferences. Design and implement model-aided workflow for high-profile/high-value projects in both innovator and generic product pipelines. EDUCATION AND EXPERIENCE : Requires a Ph.D. in Chemical Engineering and 5 years of experience in job offered or 5 years of experience in the Related Occupation RELATED OCCUPATION : Senior Scientist or any other job title performing the following job duties: Developing drying model for flow through parts Designing and building pilot rig for drying studies of flow through parts Extending the model and experimental rig to filters Selecting suitable software package for the drying model development. Identifying the relevant software platform (COMSOL Multiphysics) and purchasing software and the necessary hardware. Identifying suitable training opportunities for improving modelling expertise across the modelling community within the company. Developing the drying model to transfer to business unit where it was employed in unit operations for drying of manufactured parts. Using state-of the-art drying rig to validate drying model. Presenting to key personnel on a regular basis. Contributing to presentations at conferences and meetings. Initiating modification of the unit to accommodate the relevant part for trial work for urgent business request. Coordinating the modification program and liaised with the team to ensure that the unit would be ready for the trial, and was responsible for the capital project and sanction. Using EHS requirements including Design & Hazard Studies, Risk assessment, prediction of Standard Operating Procedures & Assessments of chemical usage (UK COSHH (Control of Substances Hazardous to Health)). JOB TIME : Full Time #LI-DNI
Created: 2024-09-10