Sr. Scientist, PK/PD Bioanalytics

About Firefly Bio:Firefly specializes in Degrader Antibody Conjugates (DACs) which combine the unique strengths of ADCs with selective protein degraders. Our mission is to unlock the full potential of bioconjugates and develop medicines with long-lasting benefits for patients. We are establishing an expert team to build state-of-the-art platform capabilities for the invention and development of innovative drug conjugates. Our company culture is built on the values of Focus, Integrity, Respect and Energy. We are looking for passionate individuals committed to making an impact on the future of medicine.Position Summary:The Sr. Scientist, Bioanalytics will perform bioanalytical measurements for preclinical PK and in vivo studies and will characterize the in vitro and in vivo stability and function of antibodies and antibody-drug conjugates (ADC) using analytical methods. The position is lab-facing and on-site. Title and compensation package will be based on prior experience.Responsibilities:Design, validate and execute bioanalytical assays to measure properties of ADCs in blood and in tissue samples.Develop and implement highly quantitative ELISA and other ligand binding assays, including assays for ADA assessment. Collect and analyze data from PK, in vivo efficacy, and in vivo tolerability studies, including NHP studies, and provide detailed reports and interpretation.Assist with ELISA and Western blot analysis of PD markers and intracellular catabolite measurements as needed.Assist with measurement of in vitro and in vivo stability of ADCs, quantification and identification of released catabolite in vivo using MS-based or ELISA assays.Participate in project teams and advise on PK/PD studies.Requirements and Experience:Ph.D., M.S., or B.S. degree in a relevant scientific discipline with 5+ years of work experience.Strong hands-on experience with ELISA-based measurements of ADCs in blood and tissue samples.Excellent knowledge of analytical methods and instrumentation (MSD, GyroLab, JESS, MS etc.).Strong expertise in developing, validating, and executing quantitative assays.Experience with PK/PD modeling of bioconjugates and biotherapeutics.Highly organized, diligent, and quality focused with good computer and documentation skills.Creativity and problem-solving skills paired with ability to excel in a highly collaborative environment.Excellent oral and written communication and interpersonal skills.Additional Skills:Experience with MS-based methods to detect ADC catabolites in blood and tissue is highly desired.BenefitsEvery team member is essential in shaping Firefly Bio's culture and science and for our success. We offer competitive compensation packages including stock options and the opportunity to be part of ground-breaking research. Firefly Bio is an equal opportunity employer and will consider all applicants for employment. Firefly Bio does not discriminate based on race, sex, color, religion, age, national origin, marital status, disability, veteran status, genetic information, sexual orientation, gender identity or any other reason prohibited by law in provision of employment opportunities and benefits.

Created: 2025-02-14