Senior Research Associate, In Vivo Pharmacology

This is a six month contract that will either be extended or converted to an FTERole and Responsibilities:Execute in vivo studies (i.e. animal handling, performing IV/IP/SC injections, cell line inoculations, tumor volume measurements, tissue harvest and processing) and various in vitro and ex vivo studiesHigh proficiency in IV tail vein injection is an absolute requirementIsolate primary cells, including immune cells, from blood and tissuesMaintain cell lines or differentiate primary monocytes to different lineagesDesign flow cytometric analysis panels and perform subsequent analyses on human and murine immune and/or tumor cellsPerform ADCC, ADCP, and other cell-based assaysConduct biochemical assays and bead-based immunoassays (Western blot, ELISA, MSD, Luminex etc)Adhere strictly to SOPs for non-clinical and clinical sample processing and flow cytometry analysisProcess, analyze and present data in project meetingsWork collaboratively with other researchers to advance various therapeutic antibodies in different cancer types and autoimmune indicationsKeep detailed records of protocols and workflowEducation, Experience and Qualification Requirements:BS or MS degree in cell biology, immunology or related field, and 2+ years of experience in academia or biopharmaceutical industry.Core Competencies, Knowledge and Skill Requirements:Requirement that candidate has hands-on expertise running in vivo studies and executing various animal handling procedures, such as IV/IP/SC injections, cell line inoculations, tumor volume measurements, tissue harvestBroader knowledge of immunology and good technical expertise in cellular and molecular immunologyRoutine literature search and communication with technical support to optimize and establish new techniques Knowledge of sterile tissue culture techniquesExperience with tissue processing, primary cell isolation and culture2+ years of multi-color flow cytometryExperience with plate-based ELISAs, electrochemiluminescence (ECL)- based (e.g., MSD platform) and/or bead-based (e.g., Luminex multiplex platform) immunoassaysData processing and analysis software (Flowjo, GraphPad Prism, ImageJ)Excellent oral/written communication skills Highly motivated and willing to adapt and learn new techniques to support drug development efforts Engage to work collaboratively within teams to deliver exceptional resultsMust be well organized, diligent, and willing to adapt to a fast-paced research environmentExperience with in vivo animal studies, including animal handling, performing routine injections, necropsy, collection of blood and tissues a strong plusImmunohistochemistry a strong plus

Created: 2025-02-06