Senior/Director of Biology

The Director/Sr. Director of Biology will be instrumental in expanding our capabilities to functionally characterize proprietary ADC's and in identifying and validating target indications. They will oversee a team of biologists and will participate in evaluating novel drug conjugates for applications in oncology, and other areas of unmet medical need. Additionally, the role will be responsible for program leadership and have the opportunity to propose novel treatment ideas. The title and compensation package will be based on experience and relevant skills. This is an on-site role with lab-facing responsibilities.Responsibilities:Oversee and manage a high functioning team of biologists responsible for functional characterization of degrader based bioconjugatesCo-lead/lead drug discovery projects and assist in preparing documents to support IND filingsMaintain and expand in-house capabilities to perform in vitro experiments with high throughput and characterize the MoA of innovative payloadsLead efforts for evaluation of antigen and target expression in cells and tissuesIdentify, design, plan and establish cell based and biochemical assays and support team in assay development and optimization, including troubleshooting as neededDesign and manage CRO studiesPropose novel drug conjugate targets and treatment conceptsParticipate in project teams, actively participate in the development of an innovative product portfolio and advise company leadershipMentor and develop staff and support the development of colleaguesRequirements and Experience:Ph.D. in cancer biology, immunology, or related discipline10+ years of industry experience in drug development research and 6+ years of successful management/leadershipExperience in leadership of drug discovery programs including IND planning and submissionsStrong hands-on experience in designing and executing in vitro and in vivo studies to validate targets and treatment ideas using ADCs, mAbs, degraders or other targeted therapiesGood understanding and utility of bioinformatic tools for target validation and biomarker developmentExperience with translational methods and analyses including IHC, transcriptomics, genomics and proteomicsStrong background in cancer biology, ADCs (antibody drug conjugates) and drug discovery including managing experiments at CROsDemonstrated leadership qualities as manager of a core functionDemonstrated success in collaborative planning and execution as a project team leaderCreativity and problem-solving skills paired with the ability to excel in a highly collaborative environmentComfortable working in a dynamic and fast paced environment.Excellent oral and written communication and interpersonal skills

Created: 2025-02-03