Principal Scientist

Principal Scientist, Immune-OncologyCanton (Greater Boston), MAFull timeJob Description:We seek a dynamic and collaborative Principal Scientist to spearhead our Immune-Oncology Drug Development efforts. The Principal Scientist will design, conduct, and analyze key mechanism-of-action studies, support lead optimization, and candidate development studies, and establish early signs of efficacy, through proof-of-concept studies using in vitro, ex vivo, and in vivo models. This pivotal role demands a hands-on scientist who thrives in a dynamic, fast-paced environment and is comfortable juggling multiple responsibilities within a resource-limited setting. In this role, you will take full ownership of Immune-Oncology projects, ensuring their success by leveraging your expertise, creativity, and resilience. Key Responsibilities:Manages small-molecule and biological drug discovery programs, overseeing all phases of project execution with a focus on R&D outcomes.Spearheads the conceptualization and design of drug discovery programs to ensure the development of innovative Immune-Oncology therapies while taking full ownership of project outcomes.Design and perform mechanism of action studies.Work collaboratively with cross-disciplinary teams, including Medicinal Chemistry, Structural Biology, Protein Chemistry, and Biophysics.Identify and develop short-, mid-, and long-term R&D objectives alongside senior management.Prioritize and coordinate research activities and allocate resources between internal staff and external contract research organizations (CROs).Proactively communicate project strategy, anticipate potential issues, and recommend appropriate resource decisions.Stays informed of innovative methods and technologies and acts as a scientific thought leader within the company.QualificationsPhD and/or MD with a primary focus in Immunology, Oncology, Cellular or Molecular Biology, or Pharmacology.6-8 years of relevant experience in a dynamic, fast-paced environment; 5- years of industry experience preferred.Substantial expertise in Immune-Oncology drug development and a thorough understanding of preclinical drug development strategy with a deep understanding of pharmacodynamic principles and biomarker discovery. IND-enabling studies knowledge desired.Demonstrable hands-on experience in all aspects of hit-generation, advancing small molecule or biological drugs through lead optimization to candidate selectionStrong track record of critical thinking and scientific achievements as demonstrated by publications in scientific journalsExpertise in managing, and running preclinical studies, including designing and implementing protocols and SOPs.Strong data management and visualization skills, with experience collaborating with other scientists to enhance data analysis and representation.Outstanding analytical, research, and communication skills (written and oral)Exceptional organizational, project, and people management skills, demonstrating leadership informed by deep expertise and a commitment to innovation.A builder and enabler by nature, this role is suited for someone eager to advance life-saving drugs into the clinic and significantly impact the field.Job Type: Full-time, Work Permit, Equal Opportunity Employment. If you are interested send us your CV /Resume and a note to our recruiting team.

Created: 2025-01-15