Scientist/Senior Scientist, Technology Development

Caribou Biosciences is a leading clinical-stage CRISPR genome-editing biopharmaceutical company dedicated to developing transformative therapies for patients with devastating diseases. Our next-generation genome-editing technology enables superior precision to develop cell therapies that are armored to potentially improve activity against diseases. We believe the future of cell therapy is off-the-shelf, and we are advancing our pipeline of off-the-shelf, or allogeneic, cell therapies from our CAR-T cell therapy platform as readily available treatments for patients with hematologic malignancies and autoimmune diseases.Members of the Caribou herd open their minds to new ideas and welcome diverse perspectives. We proudly assert that teams do their best work when their members are personally engaged, their ideas are taken seriously, and contributions are recognized. Members of the herd work from our headquarters in Berkeley, California, or remotely.About the RoleWe are seeking a ScientistSenior Scientist to join our Technology Development group to support multiple early-stage projects focused on the preclinical discovery and development of CAR-T cell therapy candidates and in vivo CRISPR therapeutics. Working in a collaborative and dynamic environment, you will lead research efforts to develop and optimize in vivo CRISPR platforms for therapeutic applications. This is an opportunity for a talented scientist to drive discovery and Caribou's next-generation CRISPR therapy programs.Responsibilities include:Design and Develop Genome Editing Strategies: Lead the design and optimization of CRISPR-based genome editing tools for in vivo applications, focusing on precision, efficiency, and safetyIn Vivo Model Development: Establish and utilize relevant animal models to evaluate the performance of CRISPR systems in various tissues and disease contextsDelivery System Optimization: Develop and test innovative delivery systems, such as lipid nanoparticles (LNPs) or viral vectors, to ensure effective and targeted delivery of CRISPR components to desired tissuesData Analysis and Interpretation: Perform genomic and transcriptomic analyses (e.g., NGS, qPCR, ddPCR) to assess on-target and off-target editing outcomes, integration events, and gene expression changesCollaboration and Leadership: Provide scientific guidance to junior team members, foster collaboration across interdisciplinary teams, and manage external research partnerships as neededProject Management: Drive projects from conceptualization through execution, ensuring alignment with company timelines and goalsRequirements:Ph.D. in Molecular Biology, Genetics, Biochemistry, Neuroscience or a related fieldMinimum 3 years of relevant experience (postdoctoral or industry)Hands-on experience with in vivo models (e.g., mouse, rat, or non-human primates), including study design, execution, and analysisProficiency in molecular biology techniques, including cloning, PCR, and NGS library preparationExperience in planning and executing in vitro functional assaysProven track record of problem solving and the ability to adapt and integrate new technologies into existing projectsHighly organized with excellent communication and critical thinking skills. Self-motivated with a strong collaborative mindsetAbility to develop and mentor a team of researchersComfort in a fast-paced environment and ability to adjust workload based upon changing prioritiesStrong analytical and problem-solving skills with a detail-oriented mindsetAbility to manage multiple projects and work both independently and in a team-oriented environmentExcellent communication and presentation skills for conveying complex scientific conceptsInnovative mindset with a passion for advancing genome editing technologiesDesired experience:Familiarity with delivery technologies such as AAV and LNP in animal modelsMouse genetics and transgenic animal model generationExperience with Next-Generation Sequencing (NGS) platformsExperience in multi-parameter flow cytometry and data analysisFamiliarity with immune cell signaling pathways governing immune response, proliferation, differentiation, and metabolismExperience designing and performing genetic engineering on cultured mammalian cellsKnowledge of regulatory requirements and preclinical study design for therapeutic developmentAt this time relocation assistance is not available for this role. Our preference is for applicants local to the San Francisco Bay Area.Caribou compensation and benefits include:Comprehensive compensation package, which includes competitive salary, bonus, and equity for all employeesSalary Range: $135,000 to $165,000 - This represents the present low and high end of the Company's pay range for this position. Actual pay will vary based on various factors, including but not limited to location, skill, experience, and performance.Generous paid vacation time, in addition to company-observed holidays and floating holidaysExcellent medical, dental, and vision insurance401(k) retirement savings plan, which includes matching employer contributionsEmployee stock purchase plan (ESPP)Tuition reimbursement programThe benefits and stock purchase described above are subject to the terms and conditions of any governing plans, policies, practices, agreements, or other materials or documents as in effect from time to time, including but not limited to terms and conditions regarding eligibility.Caribou is an equal opportunity employer and does not discriminate based on race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law. In addition, Caribou prohibits the harassment of any individual on any of the bases listed above or any other characteristics protected under federal, state, or local laws.Legal authorization to work in the United States is required. In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire.We do not accept unsolicited resumes or candidate submissions from staffing agencies. All agencies must have a valid written agreement with Caribou Biosciences, Inc.for service in place. Any resume or candidate submitted by a staffing agency without such an agreement in place will be considered unsolicited, and Caribou Biosciences, Inc. will not be obligated to pay any referral or placement fee.#Li-Onsite

Created: 2025-03-12